My blood -brain barrier has been compromised since I was 12. last week fixed by surgery. was this the problem?
It would be very difficult to design an experiment to show my type of reaction to MSG
If you took a random sample of 10,000 people maybe one or two might have a reaction. this would not be statistically significant. Only to the two affected ( With a peanut allergy one could be dead -still not statistically significant)
You could ask people who thought they had an allergy, do cognitive and physiological tests before and after MSG
Again, poor research design which may be howled down by the scientific community
You could feed rats MSG to find LD50 and find MSG was extremely safe.
How could research be designed? I would love to do some.
here is some work that has been done
Quote:
The monosodium glutamate symptom complex: assessment in a double-blind, placebo-controlled, randomized study.
BACKGROUND: Considerable debate swirls about the validity of symptoms described by many people after ingestion of monosodium glutamate (MSG), and the question has remained unresolved largely because of a paucity of well-designed challenge studies.
. . .
METHODS: We conducted oral challenge studies in self-identified MSG-sensitive subjects to determine whether they had a statistically significant difference in the incidence of their specific symptoms after ingestion of MSG compared with placebo.
. . .
Rechallenge revealed an apparent threshold dose for reactivity of 2.5 gm MSG.
. . ..
The mechanism of the reaction remains unknown, but symptom characteristics do not support an IgE-mediated mechanism. According to Food and Drug Administration recommendations, the symptoms, originally called the Chinese restaurant syndrome, are better referred to as the MSG symptom complex.
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The monosodium glutamate symptom complex: assessme...[J Allergy Clin Immunol. 1997] - PubMed Result
Probably the best paper I could find without doing a Ph.D..
So, as i found in my case, reaction is dose dependant. Does this build up or does it have to be given in one hit? Does the health of the subject at the time effect/affect this?
I don't know how strictly medical studies like this help
Quote:
Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate
In newborn mice subcutaneous injectionis of monosodium glutamate induced acute neuronal necrosis in several regions of developing brain including the hypothanamus
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Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate -- Olney 164 (3880): 719 -- Science
there are a lot of studies on this topic
Quote:
The Safety Evaluation of Monosodium Glutamate1
. . .
The conclusions of a subsequent review by the Federation of American Societies for Experimental Biology (FASEB) and the Federal Drug Administration (FDA) did not discount the existence of a sensitive subpopulation but otherwise concurred with the safety evaluation of JECFA and the SCF.
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The Safety Evaluation of Monosodium Glutamate -- Walker and Lupien 130 (4): 1049 -- Journal of Nutrition
i.e.,
MSG is safe; except for. . ?
Quote:
Monosodium Glutamate induces Convulsive Disorders in Rats
H. N. BHAGAVAN*, D. B. COURSIN* & C. N. STEWART†
*Research Institute, St Joseph Hospital, Lancaster, Pennsylvania 17604
†Department of Psychology, Franklin and Marshall College, Lancaster, Pennsylvania 17604
THE physiological and pharmacological effects of L-glutamate have received much attention since its implication in the aetiology of the "Chinese restaurant syndrome"1−3. Although an excess of L-glutamic acid (GA) as the monosodium salt (MSG) was known to cause retinopathy in experimental animals4−7, brain lesions have been noticed only recently8−10.
There seems to be no agreement about its pharmacological and neurophysiological effects in humans11 and experimental animals12
.
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Monosodium Glutamate induces Convulsive Disorders in Rats
Quote:
Monosodium Glutamate Effects
John W. Olney, Norma Jean Adamo, and Albert Ratner
No abstract or summary view of this item is available. To view the full-text version, follow this link.
Article topics:
* Physiology..Rats
* Physiology..Rodentia
* Neuroscience..Glutamate
* Physiology..Mice
* Medicine..Pediatric and Congenital Heart Disease
* Endocrinology..Ovaries
* Physiology..Ovary
* Medicine..Necrosis
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http://www.sciencemag.org/cgi/conten...n/172/3980/294
Does anyone have access to this article?
Locomotor and learning deficits in adult rats exposed to monosodium-Image -glutamate during early life
The results indicate that exposure to MSG in early life in rats could lead to subtle behavioral aberrations in late adulthood.
http://www.sciencedirect.com/science...5b2f3576ed69b8
So that's what is wrong with me
(
77 articles here mostly on brain lesions as they are something that can be easily scientifically controlled and measured.
Unlike all that messy human behavioural stuff.
http://www.sciencemag.org/cgi/search...lemhwcomptitle
