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Old 01-26-2009   #9 (permalink)
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Re: How addictive is alcohol?

"Certainly the dopaminic receptors within the limbic system play an important role. Is it possible to know the numbers of these receptors in a person?"

Not in absolute terms. A receptor is nothing more than a big amine molecule on the surface of one end of a neuron or the other. Too small to count, BUT... we can tell when there are more or less of them in specific locales by watching fMRI scans and/or (to some extent) by how the person responds to various specific stimulations. I expect Cozzolino, LeDoux, Stahl, and maybe Panksepp or Watt would have something more definitive to say about this.

"And can this number be altered?"

Evidently, yes. And by a variety of interventions that run the gamut from repetitious pharmacological all the way to repetitious behavioral. We do it all the time. H**l, I'm doing it by posting on this forum. (It's -true-.)
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