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Originally Posted by TeleMad
So I guess the best advice is not to take megadoses of zinc like some people do with other vitamins and nutrients.
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These are good refs, TM. For all of the larger diameter non-trace metals (iron, calcium, magnesium, zinc) they have a lots of complicated toxic effects based (I think) mostly on the stuff they chelate in your gut. This gives each one a characateristic malabsorbtion syndrome. They tend to also each have their own native toxicity, like the ones you mentioned for zinc. The smaller diameter non-trace metals (sodium, potassium) they tend not to have any real toxicity directly, because our kidneys are pretty good at handling sodium-potassium balance. However, when we get older and our kidneys lose capacity, these metals tend to mess up fluid balance.
The trace minerals (manganese, chromium, cobalt, etc) are almost all pretty toxic if we get them in high doses. Fortunately most of those metals (except chormium) are hard to run across.
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