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05-29-2006
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#1 (permalink)
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Thinking
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Diamporphine hydrochloride and derivatives
Will diamorphine hydrochloride react with sodium hydroxide to give diamorphine free base? Yes or No.
Not a drug dealer! Its an exam question!  |
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05-29-2006
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#2 (permalink)
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Student
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Montgomery County, Maryland
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Re: Diamporphine hydrochloride and derivatives
Nope. I'm pretty sure it would not.
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05-29-2006
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#3 (permalink)
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Student
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Montgomery County, Maryland
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Re: Diamporphine hydrochloride and derivatives
ACUTALLY:
I want to change my above answer. 
My mistake.... I am fairly certain that it WOULD produce the free base form by reacting it with sodium hydroxide.
Sorry..... 
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05-29-2006
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#4 (permalink)
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Thinking
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Re: Diamporphine hydrochloride and derivatives
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Originally Posted by Mercedes Benzene
ACUTALLY:
I want to change my above answer.
My mistake.... I am fairly certain that it WOULD produce the free base form by reacting it with sodium hydroxide.
Sorry..... |
Thanks, but can you give me an idea how? An equation maybe or point me somewhere I can find one? |
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05-29-2006
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#5 (permalink)
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Creating
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Re: Diamporphine hydrochloride and derivatives
An amine hydrochloride will obviously be neutralized by sodium hydroxide solution. Look at the pKa values. Kinetics of reaction can depend on steric hindrance and electronics, e.g., 2,2,6,6-tetramethylpiperidine and 1,8-bis(dimethylamino)naphthlene.
Will NaOH do evil to other parts of your molecule?
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05-29-2006
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#6 (permalink)
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Explaining
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Re: Diamporphine hydrochloride and derivatives
OK UncleAl, now your just making up words.
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05-30-2006
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#8 (permalink)
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Doing the Impossible
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Madison, OH (when not in fantasy land)
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Re: Diamporphine hydrochloride and derivatives
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Originally Posted by UncleAl
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I am not sure what is more impressive; the flexibility or the depth.
Bill
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05-30-2006
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#9 (permalink)
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Explaining
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Kelowna, BC, Canada
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Re: Diamporphine hydrochloride and derivatives
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Originally Posted by UncleAl
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Ooch.
Impressive penetration.
Did I mention that they were very GOOD words?
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Thank goodness science is based on "survival of the fittest" rather than being a Democracy!
Buffy
Evolution is a hoot if you are one of the survivors.
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06-02-2006
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#10 (permalink)
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Thinking
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Cambridge, England
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Re: Diamporphine hydrochloride and derivatives
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Originally Posted by UncleAl
An amine hydrochloride will obviously be neutralized by sodium hydroxide solution. Look at the pKa values. Kinetics of reaction can depend on steric hindrance and electronics, e.g., 2,2,6,6-tetramethylpiperidine and 1,8-bis(dimethylamino)naphthlene.
Will NaOH do evil to other parts of your molecule?
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Mmmhhm. Yep. Yep. I see. Thanks. Haven't got a clue what you mean but thanks! Like the pic - hope thats not you!: |
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