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alxian: i'm wondering if their could be a super creature capable of tackling all known toxins and if their are any trully toxic compounds no life form can actually deal with.
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Someone suggested radiation, but first, it's not a compound, and second, as Fishteacher73 pointed out, some bacteria thrive in radiation.
You do raise an interesting question. For example, cyanide (CN-) is a poison because it binds to the final cytochrome of the electron transport chain, stopping the flow of electrons and thus the production of ATP. Yet cyanide is considered to have been prevalent during the origin of life (and many organic compounds are thought to have been formed by the repeated combining of hydrogen cynaide (HCN) molecules).
Since life can probably survive without proteins, but not without nucleic acids, and could possibly be as simple as a self-replicating RNA, the universal toxin would need to destroy nucleic acids somehow. Maybe it's just some concentrated strong acid, like H2SO4, HNO3, HCLO4, HCL, HBr, or HI.
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PS: Forgot for a moment that there are bacteria that live in highly acidic solutions. So that kills my latter idea of H2SO4 or some other strong acid being a universal poison.
Apparently, the strong acid does not make it all the way to the DNA because I believe if it did it would destroy the DNA. I'm guessing that the flow of protons into the bacterium is used to make ATP by chemiosmosis (which I know occurs in many bacteria) at the periphery of the cell, with the protons then being pumped back out of the cell in the process: if the inside became more acidic than the outside, chemiosmosis would stop - so the bacteria would need to maintain the inside at a higher pH than the outside and the continuous pumping of protons out of the cell would prevent the strong acid from destroying the DNA.