Seaweed Infusion Responsible for the Inhibition of the AIDS Virus

[CerebralEcstasy]

From the Journals of AIDS Research and Therapy.... for those of you with an interest.

Inhibition of highly productive HIV-1 infection in T cells, primary
human macrophages, microglia, and astrocytes by Sargassum fusiforme
Elena E Paskaleva , Xudong Lin , Wen Li , Robin Cotter , Michael T
Klein , Emiliy Roberge , Er K Yu , Bruce W Clark , Jean-Claude
Veille , Yanze Liu , David Y-W Lee and Mario Canki

AIDS Research and Therapy 2006, 3:15 doi:10.1186/1742-6405-3-15

Published 25 May 2006


Abstract (provisional)



Background

The high rate of HIV-1 mutation and increasing resistance to
currently available antiretroviral (ART) therapies highlight the
need for new antiviral agents. Products derived from natural sources
have been shown to inhibit HIV-1 replication during various stages
of the virus life cycle, and therefore represent a potential source
of novel therapeutic agents. To expand our arsenal of therapeutics
against HIV-1 infection, we investigated aqueous extract from
Sargassum fusiforme (S. fusiforme) for ability to inhibit HIV-1
infection in the periphery, in T cells and human macrophages, and
ability to inhibit in the central nervous system (CNS), in microglia
and astrocytes.

Results

S. fusiforme extract blocked HIV-1 infection and replication by over
90% in T cells, human macrophages and microglia, and it also
inhibited pseudotyped HIV-1 (VSV/NL4-3) infection in human
astrocytes by over 70%. Inhibition was mediated against both CXCR4
(X4) and CCR5 (R5)-tropic HIV-1, was dose dependant and long
lasting, did not inhibit cell growth or viability, was not toxic to
cells, and was comparable to inhibition by the nucleoside analogue
2', 3'-didoxycytidine (ddC). S. fusiforme treatment blocked direct
cell-to-cell infection spread. To investigate at which point of the
virus life cycle this inhibition occurs, we infected T cells and CD4-
negative primary human astrocytes with HIV-1 pseudotyped with
envelope glycoprotein of vesicular stomatitis virus (VSV), which
bypasses the HIV receptor requirements. Infection by pseudotyped HIV-
1 (VSV/NL4-3) was also inhibited in a dose dependant manner,
although up to 57% less, as compared to inhibition of native NL4-3,
indicating post-entry interferences.

Conclusions

This is the first report demonstrating S. fusiforme to be a potent
inhibitor of highly productive HIV-1 infection and replication in T
cells, in primary human macrophages, microglia, and astrocytes.
Results with VSV/NL4-3 infection, suggest inhibition of both entry
and post-entry events of the virus life cycle. Absence of
cytotoxicity and high viability of treated cells also suggest that
S. fusiforme is a potential source of novel naturally occurring
antiretroviral compounds that inhibit HIV-1 infection and
replication at more than one site of the virus life cycle.

[Michaelangelica]

An Australian doctor is trying to encourage the use of lemon juice douches in developing countries to prevent the spread of aids.
see
http://www.aids.net.au/lemons-news-mary-magdalene.htm
He calls it "The Mary Magdelene" project.

You might also be interested in the thread I started here on Violets and cyclodides

Cyclotides have a range of interesting biological activities including anti-HIV and neurotensin inhibition, anti-microbial activity and insecticidal activity.
They are found in a variety of tropical plants from the Rubiaceae and Violaceae families.
google it; there are lots of references

[CerebralEcstasy]

Thanks for the information, I will take a look at the other threads. The site you provided was interesting as well. I

knew that they had found a certain group of prostitutes that were seemingly immune to the disease but hadn't heard much more on it from there on in.