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Old 06-15-2006   #1 (permalink)
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Beer protects your prostate
Fromhttp://www.abc.net.au/science/news/health/HealthRepublish_1661861.htm
Tuesday, 13 June 2006

cheers!

The good news is that beer may prevent prostate cancer. The bad news is that you'll destroy your liver if you drink enough to have any effect (Image: iStockphoto)

One of the main ingredients in beer appears to thwart prostate cancer, according to findings released by US researchers.

But you would have to quaff more than 17 pints to imbibe a medically effective dose of xanthohumol, the apparently cancer-fighting antioxidant found in hops, says researcher Emily Ho.

"From my studies, you would have to drink an awful lot of beer," says Ho, assistant professor of health and human science at Oregon State University


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Old 06-15-2006   #2 (permalink)
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http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract
--


1: Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14813-8. Epub 2005
Sep 28. Related Articles, Links

Pomegranate fruit juice for chemoprevention and chemotherapy of
prostate cancer.


Malik A, Afaq F, Sarfaraz S, Adhami VM, Syed DN, Mukhtar H.

Department of Dermatology, University of Wisconsin, Madison, WI 53706, USA.

Prostate cancer is the most common invasive malignancy and the
second leading cause of cancer-related deaths among U.S. males, with a
similar trend in many Western countries. One approach to control this
malignancy is its prevention through the use of agents present in diet
consumed by humans. Pomegranate from the tree Punica granatum
possesses strong antioxidant and antiinflammatory properties. We
recently showed that pomegranate fruit extract (PFE) possesses
remarkable antitumor-promoting effects in mouse skin. In this study,
employing human prostate cancer cells, we evaluated the
antiproliferative and proapoptotic properties of PFE. PFE (10-100
microg/ml; 48 h) treatment of highly aggressive human prostate cancer
PC3 cells resulted in a dose-dependent inhibition of cell growth/cell
viability and induction of apoptosis. Immunoblot analysis revealed
that PFE treatment of PC3 cells resulted in (i) induction of Bax and
Bak (proapoptotic); (ii) down-regulation of Bcl-X(L) and Bcl-2
(antiapoptotic); (iii) induction of WAF1/p21 and KIP1/p27; (iv) a
decrease in cyclins D1, D2, and E; and (v) a decrease in
cyclin-dependent kinase (cdk) 2, cdk4, and cdk6 expression. These data
establish the involvement of the cyclin kinase inhibitor-cyclin-cdk
network during the antiproliferative effects of PFE. Oral
administration of PFE (0.1% and 0.2%, wt/vol) to athymic nude mice
implanted with androgen-sensitive CWR22Rnu1 cells resulted in a
significant inhibition in tumor growth concomitant with a significant
decrease in serum prostate-specific antigen levels. We suggest that
pomegranate juice may have cancer-chemopreventive as well as
cancer-chemotherapeutic effects against prostate cancer in humans.

PMID: 16192356 [PubMed - indexed for MEDLINE]


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Old 06-15-2006   #3 (permalink)
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Some interesting new research:

Very Hot chillies help prostrate cancer in vitro and in animal studies

http://news.bbc.co.uk/1/hi/health/4805190.stm

Ignore the stuff on chillies causing stomach cancer, It’s rubbish.

“Dr Soren Lehmann, who led the study, said: "Capsaicin had a profound anti-proliferative effect on human prostate cancer cells in culture.

"It also dramatically slowed the development of prostate tumours."


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Old 06-15-2006   #4 (permalink)
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This is an interesting ethnobotanical interview about an Australian "de-tox" & anti-cancer plant.
http://www.abc.net.au/centralqld/stories/s1129664.htm

Gumbi Gumbi/cumbi cumbi AKA Berrigan, bitter bush, butter bush, cattle bush, cheesewood, locketbush, meemei, native apricot, native willow, poison berry tree, snotty gobbles, western pittosporum.
Botanical name is pittosporum phylliraeoides.

Picture?
http://www.alicesprings.nt.gov.au/co...nts.asp?id=120


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Old 06-15-2006   #5 (permalink)
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Phytotherapeutics to Quench Excessive
Testosterone Function
http://www.douglaslabs.com/pdf/nutri...sfunctions.pdf
Androgen excess, affecting up to 10% of women, places
these women at great risk for insulin resistance, diabetes,
dyslipidemias, cancers and cardiovascular disease.95,96
Phytoantiandrogens are a class of phyto-compounds that
decrease tissue sensitivity to androgens or decrease
androgen activity, often through 5-alpha-reductase
inhibition, which decreases conversion of testosterone to the
more androgenic dihydrotestosterone.
These actions are most likely due to the presence of free fatty acids such as
palmitic-acid and stearic-acid as well as the phytosterol
beta-sitosterol, all of which have 5-alpha-reductase
inhibiting activity.97,98,99
These three constituents are present
in Serenoa repens, Ocimum sanctum and Trigonella
foenum-graecum.
Palmetic acid is also an active component
within Foeniculum vulgare and Urtica dioca. Foeniculum
vulgare and Pygeum africanum
also contain betasitosterol.
98,99 Some phytoantiandrogens also have
antihyperglycemic, antihyperlipidemic, and antiinflammatory
properties, all of which greatly benefit women
with hyperandrogenism.
Saw Palmetto's (Serenoa repens) antiandrogenic
properties are attributed to inhibitory affects on 5-alphareductase
due to a high content in the free fatty acids and
beta-sitosterol.100,101 Anti-inflammatory properties have also
been noted in Serenoa repens.102
Fennel (Foeniculum vulgare), traditionally considered an
anti-androgen, has demonstrable anti-hirsutism and antiinflammatory
properties103,104 in part due to palmitic acid
and beta-sitosterol. The anti-androgen properties of
Nettles(Urtica dioica) may be due to palmitic acid, as well as other
free fatty acids such as oleic acid, linoleic acid and linolenic
acid.98,99 Antihyperglycemic and anti-inflmmatory effects
have also been demonstrated for Urtica dioica.105,106,107
Holy Basil (Ocimum sanctum) displays significant antiandrogenic
affect in androgen responsive tissues, an effect
that was reversible and returned to normal two weeks after
the withdrawal of treatment.108,109
Sedative properties have
also been identified in Ocimum sanctum, an adaptogen in
Ayurvedic medicine which demonstrates antistressor
properties to adverse stimuli as well as toxic
substances.110,111,112 Anti-inflammatory, antihyperglycemic
and antihyperlipidemic action have also been documented
in Holy Basil.113-118
Fenugreek (Trigonella foenum-graecum) has antiandrogen
activities, due to beta-sitosterol, palmitic-acid
and stearic-acid, and also has the ability to lower total
cholesterol, LDL, VLDL cholesterol and triglycerides
significantly.119-122 The anti-hyperglycemic and antiinflammatory
properties noted in fenugreek are of
additional benefit.123,124
The anti-androgen properties of Pygeum (Pygeum
africanum)
may be due to beta-sitosterol and other sterols
that suppress the effects of dihydrotestosterone.99,125 Antiinflammatory
properties have also been documented in
Pygeum.

reply from urologist:

Serenoa repens is the botanic name for Saw Palmetto isn't it? The 5 alpha-reductase antagonism may explain its activity. There is a minor typo, it should be dihydroxytestosterone. We're using Saw Palmetto and Trinovin as well as epilobium in men already. Maybe we should be in some women.


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Old 06-15-2006   #6 (permalink)
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Re: protecting your prostate

Bleh...

Too much reading all at once, and that second post was so dry... I don't know what 9/10 of that stuff is!
Quote:
Originally Posted by Post 2
Immunoblot analysis revealed
that PFE treatment of PC3 cells resulted in (i) induction of Bax and
Bak (proapoptotic); (ii) down-regulation of Bcl-X(L) and Bcl-2
(antiapoptotic); (iii) induction of WAF1/p21 and KIP1/p27; (iv) a
decrease in cyclins D1, D2, and E; and (v) a decrease in
cyclin-dependent kinase (cdk) 2, cdk4, and cdk6 expression.
What does that mean??

I recommend posting a brief section of the article and a link to the rest if one wishes to continue it, unless you can help explain what stuff like "Androgen" (Mentioned in post 5, and seems to be the main topic jointly with testosterone... But I have no clue what "androgen" is...) is for those of us ignorant to such knowledge.

About the only things I got were that in order to save your prostate, your gonna have to drink enough beer to ruin your kidney, pomegranate juice consumed by nude mice fights off human prostate cancer cells introduced into the mouse, and "very hot" chili peppers ward off cancer cells as well as not causing stomach cancer...


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Old 06-15-2006   #7 (permalink)
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Re: protecting your prostate

Quote:
Originally Posted by Michaelangelica
Beer protects your prostate
nuff said. Drink up



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Old 06-15-2006   #8 (permalink)
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Quote:
Originally Posted by Dark Mind
But I have no clue what "androgen" is...) is for those of us ignorant to such knowledge.
About the only things I got were that in order to save your prostate, your gonna have to drink enough beer to ruin your kidney, pomegranate juice consumed by nude mice fights off human prostate cancer cells introduced into the mouse, and "very hot" chili peppers ward off cancer cells as well as not causing stomach cancer...
Yeah you're right.
I'm doing a hydrogenbond
I really wanted to post the article about beer but had the others on file so let rip with them too.
The one on the Aussie plant is interesting try that.
Docs get worried about herbs that encourage testosterone production "androgens".
Androgen seem to promote prostate cancer, I think?
Androgen
From Wikipedia, the free encyclopedia


Androgen is the generic term for any natural or synthetic compound, usually a steroid hormone, that stimulates or controls the development and maintenance of masculine characteristics in vertebrates by binding to androgen receptors.
This includes the activity of the accessory male sex organs and development of male secondary sex characteristics.
Androgens, which were first discovered in 1936, are also called androgenic hormones or testoids.
Androgens are also the original anabolic steroids. They are also the precursor of all estrogens, the female sex hormones.
The primary and most well-known androgen is testosterone.


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Old 06-16-2006   #9 (permalink)
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I forgot about all you youngans out there
OK how about Pumpkin seed?
Pumpkin soup is great. especially" Queensland Blue"
http://www.mothernature.com/Library/...ooks/41/97.cfm

Prostate Enlargement

The prostate is a small gland that only men have. It sits just above the rectum and provides a good deal of the fluid in semen. Unlike most body parts, the prostate gland grows larger as men age, a condition known as benign prostatic hypertrophy (BPH). By age 40, 10 percent of men have some degree of prostate enlargement. But at age 50, the figure is 50 percent, and it keeps increasing as the years pass. Why is this cause for concern?

The male urethra, the tube through which urine passes, is encircled by the prostate gland. As the prostate grows larger, it pinches the urethra, causing BPH symptoms. It becomes harder to urinate forcefully, and men with BPH have difficulty emptying the bladder completely. The hallmark symptom is having to get up at night to urinate.

Throwing Down the Gauntlet

I'm betting my own prostate gland that herbal treatments work better than the most commonly prescribed drugs or surgery for controlling BPH, also called noncancerous prostate enlargement.

The prescription drugs finasteride (Proscar) and terazosin (Hytrin) have become big moneymakers because they are the only pharmaceuticals that are approved to prevent prostatic proliferation, the growth of new prostate cells that causes BPH in men over 50.

I announced my intentions to challenge Proscar with the herbal alternatives, saw palmetto, licorice and pumpkin seeds, in the early 1990s, shortly after the Food and Drug Administration (FDA) approved the drug. I did it publicly at a conference in front of dozens of officials from the FDA and the National Institutes of Health (NIH). I wanted all of the "magic bullet" proponents to see that not everyone thought that a prescription drug was the best answer for BPH.

I publicly bet my prostate gland that my mixture of saw palmetto, licorice and pumpkin seeds, which I blend into something I call Prosnut Butter (see page 370), would do the same thing that Proscar does. I also declared that it was cheaper and probably safer.

The other reason that I bet my prostate in public was that I wanted to make some progress toward fulfilling my life's ambition, which is getting the FDA to make the drug companies test their new synthetic drugs not only against an inactive substance (a placebo) but also against any known or suspected herbal alternative.

If the synthetic proves to be better than the placebo and the herbs, then, fine, approve the drug. But if the herbs prove to be better, or even reasonably close in effectiveness, then both should be approved. To recoup its investment in the research, the pharmaceutical firm could get some marketing privileges for the processed herb extract as well as its new synthetic. This way, people could have a choice between the pharmaceutical, which is always much more expensive, and the herbal alternative, which is always cheaper.

A year's supply of Proscar costs about $800. A year's supply of saw palmetto and licorice would be only a small fraction of that, and if you stocked up on pumpkin seeds around Halloween, you could get them dirt cheap, possibly even for free.

Until Proscar and Hytrin came along, the only medically recognized treatment for BPH was surgery. One procedure is known as transurethral resection of the prostate (TURP). TURP is the most common operation performed on men over 65. During a TURP, the urologist threads an instrument up the urethra and cuts away part of the prostate gland to enlarge the opening for the urethra, thus easing urine flow. TURP generally works well, but it is expensive and carries the usual risks of surgery, and recovery takes a week or two.

Proscar and Hytrin have been widely hailed as alternatives because they're cheaper and less traumatic than surgery. But herbs are cheaper still.

Herbs on Trial

The drugs keep prostate cells from proliferating by preventing the gland from converting the male sex hormone testosterone into a related compound, dihydrotestosterone, that stimulates prostate cell proliferation.

While the drugs do indeed prevent this process from occurring, the natural alternatives that I mentioned work at least as well. In fact, in my opinion, and in the opinions of many naturopathic physicians, the herbs work a whole lot better.

Proscar, especially, has definite drawbacks. Most men must take it for at least six months before any significant improvement becomes apparent. And it doesn't work for everyone. Fewer than half of men taking Proscar experience significant clinical improvement even after one year.

Proscar also has some disturbing side effects, among them decreased libido, ejaculatory problems and erection loss. In contrast, herbs like saw palmetto,licorice and pumpkin seeds are not reported to cause any of these problems.

Green Pharmacy for Prostate Enlargement

Here are the details about the herbs that I can say without reservation provide the best results.

PH_GP_3leaves Licorice (Glycyrrhiza glabra). Licorice contains a compound that prevents the conversion of testosterone to dihydrotestosterone. Taking very large doses of licorice for a long period of time can produce headache, lethargy, sodium and water retention, excessive loss of potassium and high blood pressure. Some 25 cases have been documented in the world medical literature, and the people who developed problems ate two to four ounces of reallicorice candy a day for years.

I doubt that the licorice extract in my Prosnut Butter would cause any problems. I've personally experienced no symptoms. But if you try the herbal approach to BPH, be alert to any symptoms and cu t down drastically on yourlicorice intake if you experience them.

PH_GP_3leaves Pumpkin (Cucurbita pepo). Pumpkin seeds were the traditional treatment for BPH in Bulgaria, Turkey and the Ukraine. The recommendation was a handful of seeds a day throughout adulthood.

The fatty oil in pumpkin seeds is a powerful diuretic, a fact that has caused some nay-sayers to assert that any increased urine flow has nothing
to do with relief from BPH. Pumpkin seeds, however, also contain chemicals called cucurbitacins that appear to prevent some transformation of testosterone into dihydrotestosterone.

In addition, pumpkin seeds can contain as much as eight milligrams of zinc per half-cup serving. Naturopaths Joseph Pizzorno, N.D., president of Bastyr University in Seattle, and Michael Murray, N.D, co-authors of A Textbook of Natural Medicine, suggest taking 60 milligrams of zinc per day for treating BPH. (This is much more than the Daily Value, so be sure to check with a doctor before you begin taking this muchzinc.)

Zinc has been shown to reduce the size of the prostate, presumably by inhibiting the conversion process mentioned earlier. Pumpkin seeds are also high in certainAmino acids--alanine, glycine and glutamic acid. Dr. Murray and Dr. Pizzorno report that in a study of 45 men who were given supplements of these Amino acids (200 milligrams of each) every day, the regimen significantly relieved BPH symptoms.

A half-cup serving of pumpkin seeds can have 1,150 to 1,245 milligrams of alanine, 1,800 to 1,930 milligrams of glycine and 4,315 to 4,635 milligrams of glutamic acid. That's anywhere from 5 to 20 times the doctors' daily recommendation.

For all of these reasons, plus good flavor, I stress a good quantity of pumpkin seeds in Prosnut Butter.

There are some other seeds that contain these beneficial Amino acids. Buffalo gourd seeds contain generous amounts of all three, peanuts and sesame seeds are high in glycine, and almonds, butternuts and peanuts are high in glutamic acid.

5 PUMP Pumpkin

This orange fruit is more than a Halloween prop: Its seeds contain a substance that can help relieve prostate problems.

PH_GP_3leaves Saw palmetto (Serenoa repens). Shortly after Proscar was approved by the FDA, the agency banned all nonprescription drugs for BPH. The ban was imposed for two reasons, according to Varro Tyler, Ph.D., dean and professor emeritus of pharmacognosy (natural product pharmacy) at Purdue University in West Lafayette, Indiana. First, the FDA said that no credible evidence was presented to show that any over-the-counter (OTC) products were effective. Second, the agency expressed the view that people who used the OTCs might delay getting proper medical treatment as their condition worsened.

"What the FDA overlooked," says Dr. Tyler, "was the considerable evidence in Western Europe that certain phytomedicinals (plant-based medicines) are effective in treating BPH and that people using them experience an appreciable increase in their comfort level. Perhaps the most popular of these is saw palmetto. . . . The beneficial effects include increased urinary flow, reduced residual urine and decreased frequency of urination."

Saw palmetto is a small palm tree that grows in the southeastern United States, particularly in Florida around the Everglades. Seminole Indians ate the saw palmetto seed as food; perhaps they noticed that it helped urinary problems. Whites adopted it as a diuretic to help flush excess water from the body, and over time it came to be used for BPH.

It works because it contains a compound that inhibits the action of the enzyme (testosterone-5-alpha-reductase) that turns testosterone into dihydrotestosterone. Preventing this transformation of testosterone is also the way Proscar works, butsaw palmetto does the job in a different and apparently more effective way.

To date, a half-dozen well-designed studies have shown the effectiveness of saw palmetto. In one study, a clinical trial involving more than 2,000 Germans with BPH, a daily dose of one to two grams of saw palmetto seeds (or 320 milligrams of its hexane extract) produced substantial easing of BPH symptoms.

Prosnut Butter

Do you like peanut butter and crackers? Do you think maybe you could munch a few every day as a snack? If your answer is yes, then you might even enjoy this "medicine" for benign prostate enlargement (BPH).

The three ingredients in this nutty spread, pumpkin seeds, saw palmetto and licorice, have all been shown to help prevent and relieve BPH.

To make the spread, place a half-cup or so of fresh pumpkin seeds in a blender or food processor. Open one saw palmetto capsule and pour in the contents, then add a few drops of licorice extract and blend until smooth. (You can add a few drops of Brazil nut oil if you need to make the mixture a little more spreadable.) All of these ingredients are available in most health food stores.

Use Prosnut Butter like peanut butter, eating a couple of tablespoonfuls every day. You can eat it on crackers or on bread, if you prefer, or try it with a little jelly. Since you want the ingredients to be fresh, don't mix up a big batch at once. Make just enough to last a couple of days.

PH_GP_2leaves Pygeum (Pygeum africanum). In one study, German researchers gave either pygeum or a placebo to 250 men with BPH. In the placebo group, 31 percent reported improvement, a typical response rate for a placebo. In thepygeum group, the figure was 66 percent.

The recommended dose is 50 milligrams of bark extract twice a day. Depending on the method and concentration of the extract, this could represent a gram or a kilogram of bark. Although the extracts are still available in health food stores, they are made from a species that could be endangered by overharvesting. So you might want to try the other alternatives listed in this chapter before resorting to this one.

PH_GP_2leaves stinging nettle (Urtica dioica). According to the results of another study, extracts of stinging nettle roots have successfully treated BPH. Researchers gave a few teaspoons of the extract daily to 67 men over age 60 with BPH and found that the herb significantly reduced their need to get up at night to urinate. The herb apparently has some inhibitory effect on the conversion of testosterone. German medical herbalists recommend two to three teaspoons of extract a day to treat BPH.


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Old 10-08-2006   #10 (permalink)
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Prostate Cancer Risks Rise With Shift Work - Workers who routinely shift their hours from night work to day work quadruple their risks of getting prostate cancer.
http://www.mercola.com/2006/oct/7/pr...shift_work.htm


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